- Regeneration Clinic Treatments
Systemic Lupus Erythematosus
Our Method
Our Unique Approach to Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting various organs and tissues worldwide driven by a complex interplay of genetic predisposition, environmental triggers, hormonal factors, and dysregulated immune responses requiring a targeted, multi-faceted therapeutic approach.
SLE Disease Overview
SLE is a chronic autoimmune disease whose development involves a combination of genetic predisposition, environmental triggers, and hormonal factors. Impaired apoptotic clearance, dysregulated immune responses, complement activation, immune complex formation, and tissue inflammation all contribute to its self-sustained autoimmune process.
Challenges in SLE Treatment
The precise mechanisms underlying SLE pathogenesis are still not fully understood, resulting in a lack of effective, low-side-effect therapies for the disease. This gap has driven growing interest in regenerative and cell-based approaches that address the root immune dysfunction rather than symptoms alone.
MSC Therapy for SLE
In recent years, mesenchymal stem cell (MSC) therapy has gained increasing attention as a potential treatment for autoimmune diseases, including SLE. MSC therapy has shown promise in improving the signs and symptoms of refractory SLE by modulating the activity of key immune cell populations involved in driving the disease process.
MSC Immunoregulatory Mechanisms
MSC therapy promotes the proliferation of Th2 and Treg cells immune cells involved in regulating immune responses while inhibiting the activity of Th1, Th17, and B cells. Treatment response may vary based on factors associated with both the MSCs themselves and individual patient characteristics, guiding a personalised approach to each case.