A beautiful, dynamic city that provides a one-of-a-kind cultural experience, spectacular natural surroundings, and great tourism infrastructure.
A Safe City
One of the most significant advantages of visiting Panama City is its excellent security reputation. Panama has made considerable advances in upgrading its security measures in recent years, making it one of the safest countries in Central America. The city has a low crime rate, and the government has taken many precautions to protect its residents and visitors.
A melting pot of races and cultures
Furthermore, Panama City has a diversified and inviting populace. Locals are polite and eager to assist guests, making the city a welcome and warm location to visit. Visitors are also drawn to the city’s rich history and culture, which includes numerous museums, galleries, cultural events and of course, the Panama Canal.
No visit to Panama City is complete without seeing the engineering marvel of the Panama Canal. Admire the huge locks through which huge ships connect the Atlantic and Pacific Oceans. Learn more about the history and significance of this legendary waterway through interactive exhibits and museums. Don’t miss the opportunity to experience the wonders of the canals up close by taking a boat tour. A testament to human ingenuity, the Panama Canal is a must-see attraction that will amaze you.
Gastronomy
Prepare your taste buds for a special gastronomic journey in Panama City. Our city is known for its diverse gastronomic scene with a mix of Indigenous, Spanish, Afro-Caribbean and international influences. Enjoy traditional Panamanian dishes such as sancocho (hearty chicken soup), ceviche (marinated seafood) and arroz con pollo (chicken and rice), or indulge in international cuisine at world-class restaurants. Whether you’re a foodie or an inquisitive explorer, Panama City’s gastronomy will leave you craving for more.
Zona Libre de Colon
For the ultimate retail therapy experience, head to the Zona Libre de Colón. As one of the largest duty-free zones in the world, it offers an extensive array of products at unbeatable prices. From high-end fashion brands to electronics, jewelry, and more, you’ll find everything you desire in this shopper’s paradise. Take advantage of tax-free shopping and explore the countless shops and boutiques. The Zona Libre de Colón promises a memorable retail adventure that will satisfy even the most discerning shoppers.
Transportation
In terms of infrastructure, Panama City has excellent transportation options, including the Panama Metro, a rapid transit system, the first subway system in Central America, a modern international airport, well-developed highways, and a friendly public transportation system. The city also offers a wide range of accommodation options, from budget hostels to luxury hotels.
A tropical paradise
Panama City also has some of the world’s most spectacular natural settings, including lovely beaches, tropical jungles, and national parks. Hiking, surfing, and fishing are among the many outdoor activities available to visitors, making it a perfect destination for thrill seekers.
References
Amyotrophic Lateral Sclerosis
References
Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies, 27(10), 1918-1929. https://doi.org/10.1111/ene.14393
Sivandzade, F., & Cucullo, L. (2021). Regenerative stem cell therapy for neurodegenerative diseases: An overview. International Journal of Molecular Sciences, 22(4), 2153. https://doi.org/10.3390/ijms22042153
Shen, Z., Huang, W., Liu, J., Tian, J., Wang, S., & Rui, K. (2021c). Effects of mesenchymal stem Cell-Derived exosomes on autoimmune diseases. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.749192
Rheumatoid arthritis
References
Scherer, H., Häupl, T., & Burmester, G. R. (2020). The etiology of rheumatoid arthritis. Journal of Autoimmunity, 110, 102400. https://doi.org/10.1016/j.jaut.2019.102400
Sarsenova, M., Issabekova, A. S., Abisheva, S. D., Rutskaya-Moroshan, K., Ogay, V., & Saparov, A. (2021). Mesenchymal stem Cell-Based therapy for rheumatoid arthritis. International Journal of Molecular Sciences, 22(21), 11592. https://doi.org/10.3390/ijms222111592
Systemic Lupus Erythematosus
References
Fava, A., & Petri, M. (2019). Systemic lupus erythematosus: Diagnosis and clinical management. Journal of Autoimmunity, 96, 1–13. https://doi.org/10.1016/j.jaut.2018.11.001
Li, A., Guo, F., Pan, Q., Chen, S., Chen, J., & Liu, H. (2021). Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.728190
Multiple Sclerosis
References
Dobson, R., & Giovannoni, G. (2019). Multiple sclerosis – a review. European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies, 26(1), 27–40. https://doi.org/10.1111/ene.13819
Jafarzadeh Bejargafshe, M., Hedayati, M., Zahabiasli, S., Tahmasbpour,E.,Rahmanzadeh,S., & Nejad-Moghaddam, A. (2019). Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis. Stem Cell Investigation, 6, 44. https://doi.org/10.21037/sci.2019.10.06
Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European Journal of Neurology, 27(10), 1918–1929. https://doi.org/10.1111/ene.14393
Sivandzade, F., & Cucullo, L. (2021). Regenerative stem cell therapy for Neurodegenerative Diseases: An Overview. International Journal of Molecular Sciences, 22(4), 2153. https://doi.org/10.3390/ijms22042153
IBD Inflammatory bowel disease
References
Inflammatory bowel disease (IBD). (2023b, April 17). Centers for Disease Control and Prevention. https://www.cdc.gov/ibd/
Ko, J. Z., Johnson, S., & Dave, M. (2021c). Efficacy and Safety of Mesenchymal Stem/Stromal cell therapy for inflammatory bowel Diseases: An Up-to-Date Systematic Review. Biomolecules, 11(1), 82. https://doi.org/10.3390/biom11010082
Systemic vasculitis
References
Shen, Z., Huang, W., Liu, J., Tian, J., Wang, S., & Rui, K. (2021e). Effects of mesenchymal stem Cell-Derived exosomes on autoimmune diseases. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.749192
Liu, Y., Yan, L. M., Wan, L., Xiang, T. X., Le, A., Liu, J. M., … & Zhang, W. (2020). Viral dynamics in mild and severe cases of COVID-19. Cell & Bioscience, 10(1), 1-7. https://www.nature.com/articles/s41419-020-2542-9
Angina/Coronary Heart Disease
References
National Center for Biotechnology Information. (2016). Drinking Water Arsenic and Cardiovascular Disease. Environmental Health Perspectives, 124(6), A106-A107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958723/
Yun, C. W., & Lee, S. Y. (2019). Enhancement of functionality and therapeutic efficacy of Cell-Based therapy using mesenchymal stem cells for cardiovascular disease. International Journal of Molecular Sciences, 20(4), 982. https://doi.org/10.3390/ijms20040982
Xiong, Y., Gong, Z., Tang, R., & Yang, Y. (2021). The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics, 11(3), 1046–1058. https://doi.org/10.7150/thno.53326
Cushing, K., & Higgins, P. D. R. (2021). Management of Crohn disease: A review: A review. JAMA: The Journal of the American Medical Association, 325(1), 69-80. https://doi.org/10.1001/jama.2020.18936
Wang, R., Yao, Q., Chen, W., Gao, F., Li, P., Wu, J., Yu, J., & Cao, H. (2021). Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Research & Therapy, 12(1). https://doi.org/10.1186/s13287-021-02533-0
Ulcerative Colitis
References
Gajendran, M., Loganathan, P., Jimenez, G., Catinella, A. P., Ng, N., Umapathy, C., Ziade, N., & Hashash, J. G. (2019). A comprehensive review and update on ulcerative colitis. Disease-a-Month: DM, 65(12), 100851. https://doi.org/10.1016/j.disamonth.2019.02.004
Hosseini-Asl, S.-K., Mehrabani, D., & Karimi-Busheri, F. (2020). Therapeutic effect of mesenchymal stem cells in ulcerative colitis: A review on achievements and challenges. Journal of Clinical Medicine, 9(12), 3922. https://doi.org/10.3390/jcm9123922
Neurological conditions
References
Guy, R., & Offen, D. (2020). Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes. Biomolecules, 10(9), 1320. https://doi.org/10.3390/biom10091320
Barthels, D., & Das, H. (2020). Current advances in ischemic stroke research and therapies. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165260. https://doi.org/10.1016/j.bbadis.2018.09.012
Campbell, B. C. V., De Silva, D. A., Macleod, M. R., Coutts, S. B., Schwamm, L. H., Davis, S. M., & Donnan, G. A. (2019). Ischaemic stroke. Nature Reviews. Disease Primers, 5(1), 70. https://doi.org/10.1038/s41572-019-0118-8
Kawabori, M., Shichinohe, H., Kuroda, S., & Houkin, K. (2020). Clinical trials of stem cell therapy for cerebral ischemic stroke. International Journal of Molecular Sciences, 21(19), 7380. https://doi.org/10.3390/ijms21197380
Parkinson’s
References
Pradhan, A. U., Uwishema, O., Onyeaka, H., Adanur, I., & Dost, B. (2022). A review of stem cell therapy: An emerging treatment for dementia in Alzheimer’s and Parkinson’s disease. Brain and Behavior, 12(9). https://doi.org/10.1002/brb3.2740
Multiple system atrophy (MSA)
References
Goh YY, Saunders E, Pavey S, Rushton E, Quinn N, Houlden H, Chelban V. Multiple system atrophy. Pract Neurol. 2023 Jun;23(3):208-221. doi: 10.1136/pn-2020-002797. Epub 2023 Mar 16. PMID: 36927875.
Khellaf A, Khan DZ, Helmy A. Recent advances in traumatic brain injury. J Neurol. 2019 Nov;266(11):2878-2889. doi: 10.1007/s00415-019-09541-4. Epub 2019 Sep 28. PMID: 31563989; PMCID: PMC6803592.
Chronic traumatic encephalopathy
References
Pierre K, Molina V, Shukla S, Avila A, Fong N, Nguyen J, Lucke-Wold B. Chronic traumatic encephalopathy: Diagnostic updates and advances. AIMS Neurosci. 2022 Dec 19;9(4):519-535. doi: 10.3934/Neuroscience.2022030. PMID: 36660076; PMCID: PMC9826753.
Spinal cord injury
References
Alizadeh, A., Dyck, S. M., & Karimi-Abdolrezaee, S. (2019). Traumatic spinal cord injury: An overview of pathophysiology, models and acute injury mechanisms. Frontiers in neurology, 10. https://doi.org/10.3389/fneur.2019.00282
Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019). Mesenchymal stem cells for spinal cord injury: Current options, limitations, and future of cell therapy. International Journal of Molecular Sciences, 20(11), 2698. https://doi.org/10.3390/ijms20112698
Looi, Q. H., Eng, S. P., Liau, L. L., Tor, Y. S., Bajuri, M. Y., Ng, M. H., & Law, J. X. (2020). Mesenchymal stem cell therapy for sports injuries – from research to clinical practice. Sains malaysiana, 49(4), 825-838. https://doi.org/10.17576/jsm-2020-4904-12
Arthritis & Osteoarthritis
References
Jang, S., Lee, K., & Ju, J. H. (2021). Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. International Journal of Molecular Sciences, 22(5). https://doi.org/10.3390/ijms22052619
