Traumatic spinal cord injury (SCI) is a life-altering neurological condition that has significant socioeconomic implications for patients and their caregivers. While medical management has advanced considerably, limited progress has been made in developing effective treatments to improve neurological outcomes.
Understanding Spinal Cord Injury
Traumatic spinal cord injury (SCI) is a life-altering neurological condition that has significant socioeconomic implications for patients and their caregivers. While medical management of SCI has made considerable advancements in terms of diagnosis, stabilization, survival rates, and overall well-being of SCI patients, there has been limited progress in developing effective treatment options to improve neurological outcomes.
The Secondary Injury Phase
The secondary injury phase in the pathophysiology of SCI is a critical stage characterized by uncontrolled and destructive cascades involving molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. Addressing this secondary injury is crucial for potential therapeutic interventions.
MSCs as a Therapeutic Strategy
One promising strategy that has been extensively tested is the use of mesenchymal stem cells (MSCs). MSCs have gained attention due to their ease of isolation and preservation, as well as their unique properties among other types and sources of stem cells — making them highly accessible for clinical application.
Why MSCs Stand Out
MSCs offer a unique combination of anti-inflammatory, immunomodulatory, and regenerative properties that make them especially suited for addressing the complex cascade of secondary injury in SCI. Their ability to modulate the injury environment provides a meaningful pathway toward improved neurological recovery and patient outcomes.
Referencias
Esclerosis lateral amiotrófica
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Autismo
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Artritis reumatoide
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Lupus eritematoso sistémico
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Esclerosis múltiple
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EII Enfermedad inflamatoria intestinal
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vasculitis sistémica
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Angina/Coronary Heart Disease
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Mejora de la funcionalidad y la eficacia terapéutica de la terapia celular con células madre mesenquimales para enfermedades cardiovasculares Yun & Lee
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Ulcerative Colitis
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Afecciones neurológicas
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Parkinson’s
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Traumatic brain injury
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Chronic traumatic encephalopathy
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Spinal cord injury
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Arthritis & Osteoarthritis
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Amyotrophic Lateral Sclerosis
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Rheumatoid arthritis
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Systemic Lupus Erythematosus
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Multiple Sclerosis
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IBD Inflammatory bowel disease
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Systemic vasculitis
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Angina/Coronary Heart Disease
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Ulcerative Colitis
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Neurological conditions
References
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Parkinson’s
References
Pradhan, A. U., Uwishema, O., Onyeaka, H., Adanur, I., & Dost, B. (2022). A review of stem cell therapy: An emerging treatment for dementia in Alzheimer’s and Parkinson’s disease. Brain and Behavior, 12(9). https://doi.org/10.1002/brb3.2740
Multiple system atrophy (MSA)
References
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Chronic traumatic encephalopathy
References
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Spinal cord injury
References
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Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019). Mesenchymal stem cells for spinal cord injury: Current options, limitations, and future of cell therapy. International Journal of Molecular Sciences, 20(11), 2698. https://doi.org/10.3390/ijms20112698
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Arthritis & Osteoarthritis
References
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