Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder that affects the colon, causing continuous inflammation of the mucosal lining from the rectum to varying extents of the proximal colon. UC is characterized by a relapsing and remitting course, where symptoms may flare up and then subside over time. The risk factors for UC include a combination of genetics, environmental factors, autoimmunity, and alterations in gut microbiota.

The typical presentation of UC includes symptoms such as bloody diarrhea, with or without mucus, rectal urgency, tenesmus (a feeling of incomplete bowel movement), and variable degrees of abdominal pain that is often relieved by bowel movements.

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that possess immunosuppressive properties, making them a potential treatment strategy for inflammatory bowel disorders like UC. MSCs have gained global attention for their use in cell transplantation due to their ease of expansion and their ability to home to the intestinal mucosa. Moreover, MSCs can differentiate into epithelial and other cells that directly promote repair of mucosal damage in UC. Further research is needed to fully understand how MSCs can be targeted as a promising treatment option for UC patients who have not responded well to conventional therapies.

Ulcerative Colitis

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