Psoriasis

Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. You usually get the patches on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body. Some people who have psoriasis also get a form of arthritis called psoriatic arthritis. A problem with your immune system causes psoriasis. In a process called cell turnover, skin cells that grow deep in your skin rise to the surface. Normally, this takes a month. In psoriasis, it happens in just days because your cells rise too fast. Psoriasis can last a long time, even a lifetime. Symptoms come and go. Things that make them worse include Infections, Stress, Dry skin, Psoriasis usually occurs in adults. It sometimes runs in families.

Psoriasis

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Citations and Scientific References

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References

Amyotrophic Lateral Sclerosis

References

Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies, 27(10), 1918-1929. https://doi.org/10.1111/ene.14393

Sivandzade, F., & Cucullo, L. (2021). Regenerative stem cell therapy for neurodegenerative diseases: An overview. International Journal of Molecular Sciences, 22(4), 2153. https://doi.org/10.3390/ijms22042153

Autism

References

Hodges, H., Fealko, C., & Soares, N. (2020b). Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation. Translational Pedriatrics, 9(S1), S55–S65. https://doi.org/10.21037/tp.2019.09.09

Autoinmune Diseases

References

http://www.columbia.edu/itc/hs/medical/pathophys/immunology/readings/AutoimmuneDiseases.pdf


Shen, Z., Huang, W., Liu, J., Tian, J., Wang, S., & Rui, K. (2021c). Effects of mesenchymal stem Cell-Derived exosomes on autoimmune diseases. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.749192 

Rheumatoid arthritis

References

Scherer, H., Häupl, T., & Burmester, G. R. (2020). The etiology of rheumatoid arthritis. Journal of Autoimmunity, 110, 102400. https://doi.org/10.1016/j.jaut.2019.102400

Sarsenova, M., Issabekova, A. S., Abisheva, S. D., Rutskaya-Moroshan, K., Ogay, V., & Saparov, A. (2021). Mesenchymal stem Cell-Based therapy for rheumatoid arthritis. International Journal of Molecular Sciences, 22(21), 11592. https://doi.org/10.3390/ijms222111592

Systemic Lupus Erythematosus

References

Fava, A., & Petri, M. (2019). Systemic lupus erythematosus: Diagnosis and clinical management. Journal of Autoimmunity, 96, 1–13. https://doi.org/10.1016/j.jaut.2018.11.001

Li, A., Guo, F., Pan, Q., Chen, S., Chen, J., & Liu, H. (2021). Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.728190

Multiple Sclerosis

References

Dobson, R., & Giovannoni, G. (2019). Multiple sclerosis - a review. European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies, 26(1), 27–40. https://doi.org/10.1111/ene.13819 

Jafarzadeh Bejargafshe, M., Hedayati, M., Zahabiasli, S., Tahmasbpour,E.,Rahmanzadeh,S., & Nejad-Moghaddam, A. (2019). Safety and efficacy of stem cell therapy for treatment of neural damage in patients with multiple sclerosis. Stem Cell Investigation, 6, 44. https://doi.org/10.21037/sci.2019.10.06 

(n. d.-a). Amedeolucente.it. Retrieved from https://amedeolucente.it/public/Diagnosis 

Amyotrophic lateral sclerosis

References

Masrori, P., & Van Damme, P. (2020). Amyotrophic lateral sclerosis: a clinical review. European Journal of Neurology, 27(10), 1918–1929. https://doi.org/10.1111/ene.14393    

Sivandzade, F., & Cucullo, L. (2021). Regenerative stem cell therapy for Neurodegenerative Diseases: An Overview. International Journal of Molecular Sciences, 22(4), 2153. https://doi.org/10.3390/ijms22042153 

IBD Inflammatory bowel disease

References

Inflammatory bowel disease (IBD). (2023b, April 17). Centers for Disease Control and Prevention. https://www.cdc.gov/ibd/ 

Ko, J. Z., Johnson, S., & Dave, M. (2021c). Efficacy and Safety of Mesenchymal Stem/Stromal cell therapy for inflammatory bowel Diseases: An Up-to-Date Systematic Review. Biomolecules, 11(1), 82. https://doi.org/10.3390/biom11010082 

Systemic vasculitis

References

Shen, Z., Huang, W., Liu, J., Tian, J., Wang, S., & Rui, K. (2021e). Effects of mesenchymal stem Cell-Derived exosomes on autoimmune diseases. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.749192

Fibromyalgia

References

Branch, N. S. C. a. O. (2023, April 3). Fibromyalgia. National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/fibromyalgia

Psoriasis

References

(n. d.-b). Medlineplus.gov. Retrieved from https://medlineplus.gov/psoriasis.htm

Anti-Aging

References

National Institute of health https://www.nia.nih.gov/health/what-do-we-know-about-healthy-aging

Cardiovascular Conditions

References

Centers for Disease Control and Prevention. (n.d.). Cardiovascular Diseases. Retrieved June, 2023, from https://www.cdc.gov/globalhealth/healthprotection/ncd/cardiovascular-diseases.html

Liu, Y., Yan, L. M., Wan, L., Xiang, T. X., Le, A., Liu, J. M., ... & Zhang, W. (2020). Viral dynamics in mild and severe cases of COVID-19. Cell & Bioscience, 10(1), 1-7. https://www.nature.com/articles/s41419-020-2542-9

Angina/Coronary Heart Disease

References

National Center for Biotechnology Information. (2016). Drinking Water Arsenic and Cardiovascular Disease. Environmental Health Perspectives, 124(6), A106-A107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958723/

Centers for Disease Control and Prevention. (2021). Coronary Heart Disease: Brief. CDC. Retrieved from https://www.cdc.gov/aging/publications/coronary-heart-disease-brief.html 

Enhancement of Functionality and Therapeutic Efficacy of Cell-Based Therapy Using Mesenchymal Stem Cells for Cardiovascular Disease Yun & Lee

https://www.mdpi.com/1422-0067/20/4/982

Peripheral Artery Disease

References

UTHSC Internal Medicine at Chattanooga

https://thebaronessinternalmed.com/wp-content/uploads/2020/05/NEJM-PAD-review-2016.pdf

Stem/Progenitor Cells and Their Therapeutic Application in Cardiovascular Disease

https://pubmed.ncbi.nlm.nih.gov/30406100/

Yun, C. W., & Lee, S. Y. (2019). Enhancement of functionality and therapeutic efficacy of Cell-Based therapy using mesenchymal stem cells for cardiovascular disease. International Journal of Molecular Sciences, 20(4), 982. https://doi.org/10.3390/ijms20040982

Acute Myocardial Infarction

References

White, H. D., & Chew, D. P. (2008). Acute myocardial infarction.  Lancet, 372(9638), 570 584. https://doi.org/10.1016/s0140-6736(08)61237-4

Xiong, Y., Gong, Z., Tang, R., & Yang, Y. (2021). The pivotal roles of exosomes derived from endogenous immune cells and exogenous stem cells in myocardial repair after acute myocardial infarction. Theranostics, 11(3), 1046–1058. https://doi.org/10.7150/thno.53326 

Fertility

References

Wang J, Liu C, Fujino M, Tong G, Zhang Q, Li XK, Yan H. Stem Cells as a Resource for Treatment of Infertility-related Diseases. Curr Mol Med. 2019;19(8):539-546. doi: 10.2174/1566524019666190709172636. PMID: 31288721; PMCID: PMC6806537. 

Saeed Y, Liu X. Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review. Int J Reprod Biomed. 2022 Oct 10;20(9):709-722. doi: 10.18502/ijrm.v20i9.12061. PMID: 36340664; PMCID: PMC9619121.

Gastrointestinal Disorders 

References

Digestive diseases. (n. d.). National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved from https://www.niddk.nih.gov/about-niddk/research-areas/digestive-diseases

Crohn´s Disease 

References

Cushing, K., & Higgins, P. D. R. (2021). Management of Crohn disease: A review: A review. JAMA: The Journal of the American Medical Association, 325(1), 69-80. https://doi.org/10.1001/jama.2020.18936

Wang, R., Yao, Q., Chen, W., Gao, F., Li, P., Wu, J., Yu, J., & Cao, H. (2021). Stem cell therapy for Crohn’s disease: systematic review and meta-analysis of preclinical and clinical studies. Stem Cell Research & Therapy, 12(1). https://doi.org/10.1186/s13287-021-02533-0

Ulcerative Colitis

References

Gajendran, M., Loganathan, P., Jimenez, G., Catinella, A. P., Ng, N., Umapathy, C., Ziade, N., & Hashash, J. G. (2019). A comprehensive review and update on ulcerative colitis. Disease-a-Month: DM, 65(12), 100851. https://doi.org/10.1016/j.disamonth.2019.02.004

Hosseini-Asl, S.-K., Mehrabani, D., & Karimi-Busheri, F. (2020). Therapeutic effect of mesenchymal stem cells in ulcerative colitis: A review on achievements and challenges. Journal of Clinical Medicine, 9(12), 3922. https://doi.org/10.3390/jcm9123922

Neurological conditions

References

Guy, R., & Offen, D. (2020). Promising opportunities for treating neurodegenerative diseases with mesenchymal stem cell-derived exosomes. Biomolecules, 10(9), 1320. https://doi.org/10.3390/biom10091320

Alzheimer’s

References

What is Alzheimer’s disease? (2023, enero 7). Cdc.gov. https://www.cdc.gov/aging/aginginfo/alzheimers.htm

Liu, X.-Y., Yang, L.-P., & Zhao, L. (2020). Stem cell therapy for Alzheimer’s disease. World Journal of Stem Cells, 12(8), 787-802. https://www.cdc.gov/aging/aginginfo/alzheimers.htm

What is Alzheimer’s disease? (2023, enero 7). Cdc.gov. https://www.cdc.gov/aging/aginginfo/alzheimers.htm

Stroke

References

CDC. (2023, mayo 5). About stroke. Centers for Disease Control and Prevention. https://www.cdc.gov/stroke/about.htm

Barthels, D., & Das, H. (2020). Current advances in ischemic stroke research and therapies. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165260. https://doi.org/10.1016/j.bbadis.2018.09.012

Campbell, B. C. V., De Silva, D. A., Macleod, M. R., Coutts, S. B., Schwamm, L. H., Davis, S. M., & Donnan, G. A. (2019). Ischaemic stroke. Nature Reviews. Disease Primers, 5(1), 70. https://doi.org/10.1038/s41572-019-0118-8

Kawabori, M., Shichinohe, H., Kuroda, S., & Houkin, K. (2020). Clinical trials of stem cell therapy for cerebral ischemic stroke. International Journal of Molecular Sciences, 21(19), 7380. https://doi.org/10.3390/ijms21197380

Parkinson’s

References

Pradhan, A. U., Uwishema, O., Onyeaka, H., Adanur, I., & Dost, B. (2022). A review of stem cell therapy: An emerging treatment for dementia in Alzheimer’s and Parkinson’s disease. Brain and Behavior, 12(9). https://doi.org/10.1002/brb3.2740

Multiple system atrophy (MSA)

References

Goh YY, Saunders E, Pavey S, Rushton E, Quinn N, Houlden H, Chelban V. Multiple system atrophy. Pract Neurol. 2023 Jun;23(3):208-221. doi: 10.1136/pn-2020-002797. Epub 2023 Mar 16. PMID: 36927875.

Singer W, Dietz AB, Zeller AD, Gehrking TL, Schmelzer JD, Schmeichel AM, Gehrking JA, Suarez MD, Sletten DM, Minota Pacheco KV, Coon EA, Sandroni P, Benarroch EE, Fealey RD, Matsumoto JY, Bower JH, Hassan A, McKeon A, Windebank AJ, Mandrekar JN, Low PA. Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy. Neurology. 2019 Jul 2;93(1):e77-e87. doi: 10.1212/WNL.0000000000007720. Epub 2019 May 31. PMID: 31152011; PMCID: PMC6659003.

Traumatic brain injury

References

Khellaf A, Khan DZ, Helmy A. Recent advances in traumatic brain injury. J Neurol. 2019 Nov;266(11):2878-2889. doi: 10.1007/s00415-019-09541-4. Epub 2019 Sep 28. PMID: 31563989; PMCID: PMC6803592.

Chronic traumatic encephalopathy

References

Pierre K, Molina V, Shukla S, Avila A, Fong N, Nguyen J, Lucke-Wold B. Chronic traumatic encephalopathy: Diagnostic updates and advances. AIMS Neurosci. 2022 Dec 19;9(4):519-535. doi: 10.3934/Neuroscience.2022030. PMID: 36660076; PMCID: PMC9826753.

Spinal cord injury

References

Alizadeh, A., Dyck, S. M., & Karimi-Abdolrezaee, S. (2019). Traumatic spinal cord injury: An overview of pathophysiology, models and acute injury mechanisms. Frontiers in neurology, 10. https://doi.org/10.3389/fneur.2019.00282

Cofano, F., Boido, M., Monticelli, M., Zenga, F., Ducati, A., Vercelli, A., & Garbossa, D. (2019). Mesenchymal stem cells for spinal cord injury: Current options, limitations, and future of cell therapy. International Journal of Molecular Sciences, 20(11), 2698. https://doi.org/10.3390/ijms20112698

Cerebral Palsy

References

Cerebral palsy. (1999). Brain and Nerves. https://medlineplus.gov/cerebralpalsy.html

Orthopedic and Sports Injuries

References

Looi, Q. H., Eng, S. P., Liau, L. L., Tor, Y. S., Bajuri, M. Y., Ng, M. H., & Law, J. X. (2020). Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. Sains malaysiana, 49(4), 825-838. https://doi.org/10.17576/jsm-2020-4904-12

Arthritis & Osteoarthritis

References

Jang, S., Lee, K., & Ju, J. H. (2021). Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. International Journal of Molecular Sciences, 22(5). https://doi.org/10.3390/ijms22052619

Joint pain

References

(N. d.). Frontiersin.org. Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2021.631291/ful

Joint pain and arthritis. (2022, abril 22). Cdc.gov. https://www.cdc.gov/arthritis/pain/

Sports injuries

References

NCHS pressroom - 2001 news release - sports-related injuries. (2019, mayo 24). Cdc.gov. https://www.cdc.gov/nchs/pressroom/01news/sports.htm

Xu, Y., Zhang, W.-X., Wang, L.-N., Ming, Y.-Q., Li, Y.-L., & Ni, G.-X. (2021). Stem cell therapies in tendon-bone healing. World Journal of Stem Cells, 13(7), 753-775. https://doi.org/10.4252/wjsc.v13.i7.753