Crohn´s Disease

Crohn’s disease is a chronic inflammatory condition that primarily affects the gastrointestinal tract and is becoming increasingly prevalent worldwide. Uncontrolled inflammation in Crohn’s disease can lead to long-term complications, including the development of fibrotic strictures, enteric fistulae, and intestinal neoplasia. Therefore, early and effective control of inflammation is of utmost importance. The management of Crohn’s disease should consider patient risk stratification, patient preference, and clinical factors to determine the optimal therapeutic approach.

In recent years, advances in stem cell biology and regenerative medicine have uncovered the potential use of stem cells (SCs) for the treatment of autoimmune diseases. Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have demonstrated efficacy in countering autoimmune conditions such as rheumatoid arthritis, autoimmune hepatitis, and systemic sclerosis. MSCs exhibit low immunogenicity and possess immunomodulatory properties. Randomized controlled trials have shown that local injection of MSCs can improve perianal fistulation in Crohn’s disease. HSCs transplantation has been found to restore immune tolerance and alleviate symptoms in Crohn’s disease. Stem cells have demonstrated the ability to inhibit intestinal inflammation, promote long-term mucosal healing, and significantly enhance patient quality of life, making them a valuable alternative treatment option for Crohn’s disease.

Crohn´s Disease

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